The trail is located one mile down from the Lower Manzana Trailhead (aka Lower NIRA) along Manzana Creek. The trailhead for Potrero Trail is between the two trail camps at Potrero Camp. It begins at the junction of Manzana Creek Trail 30WI3 and Potrero Canyon Trail 29W12. The trail climbs consistently, sometimes steeply, up the south face of the Hurricane Deck, passing Negus Potrero to finally reach the Hurricane Deck Trail 30W14.